Protect your pet - inside and out
Advocate, a patented combination of Imidacloprid (from Advantage) and Moxidectin, is a break-through in the treatment of parasites in dogs. Advocate treats, protects against and prevents the major parasites of your pet, inside and out.
Treat- Eliminate existing parasite infections.
Protect - Continuous coverage, as one application lasts all month.
Prevent - New infections cannot establish.
Advocate is the most convenient way to protect your pet as it is the only spot-on product to control fleas, heartworm and gastrointestinal worms in dogs. That means no more nasty tablets for your dog.
The Fast Flea Control and Prevention. Imidacloprid spreads rapidly over your pet, killing 98-100% of adult fleas within 12 hours of application. In addition, Imidacloprid controls flea larvae in the pet’s environment and reduces the incidence of Flea Allergy Dermatitis (FAD).
Heartworm Prevention. After application, Moxidectin enters your pet’s bloodstream and with monthly use will prevent heartworm infection in dogs.
Treatment, Protection and Prevention of Gastrointestinal Worms. Advocate's unsurpassed efficacy against adult, immature and L4 larval stages of hookworms and roundworms assures protection against environmental contamination and prevents reinfestation of your pet.
Control of Ear Mites. For the treatment of ear mites, Advocate is highly effective as a single dose.
Treatment and Control of Demodex. Demodex is a skin mite that can cause a potentially debilitating skin condition in dogs. Monthly application of Advocate for 2 to 4 treatments is highly effective in the treatment of this condition.
Treatment and Prevention of Sarcoptic Mange. Advocate eliminates 100% of sarcoptic mange mites after a single dose.
|Indication||Treatment and prevention of fleas (Ctenocephalides sp.). Reduces the incidence of flea allergy dermatitis; larval flea stages are killed in the surroundings of Advocate treated pets.Prevention of heartworm (Dirofilaria immitis) infection.Control of roundworms (Toxocara canis, Toxascaris leonina including larval (L4) and immature adult stages); hookworms (Ancylostoma caninum, A. braziliense (rare outside coastal areas of north Queensland, Northern Territory and northern Western Australia), Ancylostoma ceylanicum, Uncinaria stenocephala, including larval (L4) and immature adult stages of all species); and whipworm (Trichuris vulpis). Control of lice (Trichodectes canis and Linognathus setosus) for up to six weeks.Treatment and control of sarcoptic mange (Sarcoptes scabiei), ear mites (Otodectes cynotis) and generalised demodicosis (Demodex canis) in dogs and puppies.One application lasts for a month.|
|Contraindications||Administration of Advocate for Dogs to cats.|
|Actions||Imidacloprid is a chloronicotinyl nitroguanidine synthesised from the nitromethylene class of compounds. It binds to the insect's nicotinyl receptor sites on the postsynaptic neurones, disrupting normal nerve transmission. Imidacloprid kills adult fleas (Ctenocephalides sp.) rapidly, and larval flea stages in the pet's surroundings are killed following contact with the treated pet.Moxidectin is a second generation macrocyclic lactone of the milbemycin family. It interacts with GABA and glutamate gated chloride channels. The net effect is to open the chloride channels on the postsynaptic junction to allow the inflow of chloride ions and induce an irreversible resting state. This results in flaccid paralysis of affected parasites followed by their death or expulsion.|
|Precautions||Use with caution in sick, debilitated or underweight animals. Advocate may be safely applied to heartworm infected dogs, and therefore there is no absolute requirement for a heartworm test before commencing treatment. However, a diagnostic test for heartworm prior to commencement of treatment is recommended to ensure the optimum health of dogs.Advocate has no strong chemical smell. The liquid vehicle in Advocate may discolour certain surfaces and fabrics. Exclude the animal from contact with such surfaces until the product dries on the animal's coat.Harmful if swallowed. Will damage the eyes. Repeated exposure may cause allergic disorders. Avoid contact with the eyes. Wash hands after use.First Aid If product in eyes, wash it out immediately with water.|
|Dosage and Administration||Imidacloprid 10 mg/kg; moxidectin 2.5 mg/kg. Apply monthly.Dose. Dogs < 4 kg. 1 tube applied in a single spot between the shoulder blades. Dogs 4 to 10 kg. 1 tube applied in a single spot between the shoulder blades. Dogs 10 to 25 kg. 1 tube applied in a single spot between the shoulder blades. Dogs 25 to 40 kg. 1 tube divided between the shoulder blades, between the hips, and one point in between. Dogs > 40 kg. 2 tubes divided and applied between the shoulder blades, between the hips, and at one point in between. Puppies. Puppies may be treated with Advocate from 7 weeks of age. If puppies younger than 7 weeks require flea control they may be safely treated with Advantage for Dogs. For control of roundworms and hookworms, puppies require worming at 2, 4, 6 and 8 weeks of age. When worming puppies prior to commencing Advocate, use a specific worming agent such as Drontal. Once treatment with Advocate every month is commenced, worms will be continuously controlled.Flea control and prevention. Advocate has been shown to kill adult and larval fleas within 20 minutes of contact by absorption via the flea intersegmental membranes, and stops fleas from feeding in three to five minutes. Fleas are not required to bite the animal to receive a lethal dose. The successive feeding activity of fleas on pets may elicit a hypersensitivity skin disorder known as flea allergy dermatitis. Treatment of pets with Advocate rapidly kills fleas and reduces the incidence of this condition.Advocate may be used as the only product for flea control, as it breaks the flea life cycle and kills fleas emerging from the environment to reinfest the dog. More rapid resolution of heavy environmental infestations may be obtained by additional environmental control measures using a suitable registered product. It is recommended that all dogs in the same environment should be protected by Advocate for Dogs and all cats with Advocate for Cats.Heartworm prevention. Treatment with Advocate should start one month before the first exposure to mosquitoes. Advocate must be applied at one month intervals during the time of the year when mosquitoes (which carry and transmit the heartworm larvae) are present. In many areas of Australia, continuous, year round heartworm prevention is recommended. To establish a routine, it is recommended that the same day or date be used each month to administer Advocate. When replacing another heartworm preventive product, the first treatment with Advocate must be given within one month of the last dose of the previous product.Worm control and prevention. Advocate controls the major gastrointestinal nematodes of dogs but does not control tapeworms. In order to control tapeworms use Drontal or Droncit as appropriate. Dogs can become reinfested with worms, but regular use of Advocate will remove them.Treatment and control of sarcoptic mange. Advocate has been shown to eliminate 100% of sarcoptic mites (Sarcoptes scabiei) after a single dose. A second dose of Advocate a month later will result in continued improvement of the clinical signs associated with sarcoptic mange. Monthly application of Advocate will control any subsequent sarcoptic mite infestation.Treatment and control of ear mites. Advocate is highly efficacious as a single dose for the treatment of ear mites (Otodectes cynotis). Monthly application of Advocate will control any subsequent ear mite infestation.Treatment and control of generalised demodicosis. Advocate has been shown to be highly effective in the treatment of generalised demodicosis when administered at monthly intervals for two to four treatments. In a laboratory study performed on dogs naturally infested with Demodex canis, treatment with Advocate resulted in a decrease in the occurrence of erythema, casts, scales, crusts and alopecia, and a significant reduction (97.84%) in mite numbers found on skin scrapings. In a field study, all dogs enrolled in the study were 100% cured of Demodex mites.Advocate remains efficacious following shampoo treatment, swimming or exposure to rain. Prevent the pet from immersing in water until the product is dry. If washing animal use soap free shampoo before application and then apply when the coat is dry.|
|Storage||Store below 25°C (air conditioning).|
|Manufacturer||Bayer Australia Ltd|