||Treatment and control of ivermectin sensitive internal and external parasites of cattle and pigs.Cattle. Gastrointestinal nematodes: adult and immature Ostertagia ostertagi (including third and fourth stage larvae and inhibited immatures), O. lyrata, Haemonchus placei (including third and fourth stage larvae), Trichostrongylus axei, T. colubriformis, Cooperia sp. (including third and fourth stage larvae), Bunostomum phlebotomum (including third and fourth stage larvae), Oesophagostomum radiatum (including third and fourth stage larvae), and adults of Nematodirus spathiger, N. helvetianus, Strongyloides papillosus, Toxocara vitulorum and Trichuris sp.; lungworm: (adult and immature) Dictyocaulus viviparus (including inhibited stages); eyeworm: (adult) Thelazia sp.; screw worm fly: parasitic larval stages of Chrysomya bezziana (not reported in Australia but present in Papua–New Guinea); sucking lice Linognathus vituli, Haematopinus eurysternus and Solenopotes capillatus (does not provide full control of the cattle biting louse Bovicola bovis ); mites Sarcoptes scabiei var. bovis; cattle tick Boophilus microplus including organophospate, synthetic pyrethroid and amidine resistant strains.Maximum efficacy is reached four to five days after treatment. Noromectin Injectable should be alternated with dips or pour-ons when the program requires repeat treatment.Do not re-treat with Noromectin Injectable in less than the meat withholding period of 42 days.Noromectin Injectable, at the recommended dose rate, effectively controls infections with Ostertagia sp. and Cooperia sp. acquired up to seven days after treatment, and with Dictyocaulus viviparus and Chrysomya bezziana acquired up to 14 days after treatment. When used as directed, Noromectin Injectable concurrently aids in the control of Chorioptes bovis (mite).Pigs. Gastrointestinal nematodes: adults and fourth stage larvae of Ascaris suum, Hyostrongylus rubidus, Oesophagostomum sp. (nodule worm) and adults of Strongyloides ransomi * (intestinal threadworm) and Trichuris suis; kidney worms: adults and fourth stage larvae of Stephanurus dentatus; lungworms: (adult) Metastrongylus sp.; lice: Haematopinus suis; and mites: Sarcoptes scabiei var. suis. *Noromectin Injection given to pregnant sows seven to 14 days before farrowing effectively controls transmission via the milk of S. ransomi to piglets. Safety to cattle and pigs. Studies have demonstrated a wide safety margin. Pregnant and breeding cattle and pigs may be safely treated provided normal care is taken in handling.
||Ivermectin paralyses and ultimately kills parasitic nematodes, arachnids and insects by a unique effect on the nervous system of these parasites. Ivermectin activates glutamate sensitive chloride ion channels in invertebrate muscle and nerve cells, and also affects the release and binding of γ-aminobutyric acid (GABA) which opens chloride channels in nerves. The chloride channels are open when they should be closed, and signals are not received by the end cell. The process is irreversible and leads to paralysis and death of the parasite.Mammals do not have glutamate mediated chloride channels, and GABA mediated nerves occur only in the central nervous system, whereas in the invertebrate such nerves regulate the peripheral muscles. Ivermectin does not readily cross the blood brain barrier and has no notable effect on mammalian GABA binding. Therefore ivermectin has a wide margin of safety in mammals.
||Noromectin Injectable is to be given subcutaneously only.
||Not to be used for any purpose or in any manner contrary to the label unless authorised under appropriate legislation. Avoid carcass damage. Sterilise all injection apparatus by boiling (or equivalent) before use. Avoid use of strong disinfectants on apparatus. Maintain cleanliness at all times. Keep needles sharp and clean. Replace frequently. Use shortest needle possible, certainly not exceeding 15 mm. As far as possible avoid injection of animals during wet weather or in dusty conditions. This product must be injected only under the skin. If possible inject high on the neck behind the ear.Poisonous if swallowed. Avoid contact with eyes, skin and clothing.First Aid If poisoning occurs, contact a doctor or the Poisons Information Centre. Phone Australia 131 126.Disposal Dispose of empty container by wrapping with paper and putting in garbage. Discarded needles and sharps should immediately be placed in a designated and appropriately labelled sharps container. Protection of wildlife, fish, crustaceans and the environment. Do not contaminate dams, rivers or streams. Studies indicate that when ivermectin comes in contact with soil, it binds readily and tightly to the soil and becomes inactive over time. Containers and any residual contents should be disposed of safely in an approved landfill, as free ivermectin may adversely affect fish and certain water borne organisms.
|Dosage and Administration
|| Cattle. 1 mL/50 kg bodyweight (ivermectin 200 microgram/kg) by subcutaneous injection only. Dose the mob according to the heaviest animal by liveweight in each group (cows, bulls, calves, heifers, etc). Do not underdose. A representative sample of cattle should be weighed before treatment either with scales or with a weighband. Where there is a large variation in size within the group, draft into two or more lines based on bodyweight, to avoid excessive overdosing. Heavier animals (for example mature bulls) should receive an additional 1 mL for each 50 kg over 650 kg. Pigs. 1 mL/33 kg bodyweight (ivermectin 300 microgram/kg) by subcutaneous injection only, in the neck. Do not use intravenously or intramuscularly. Dose animals according to the heaviest animal by liveweight in each group (sows, gilts, boars, etc). Do not underdose. Pigs should be weighed. In young pigs, especially those below 16 kg, dosing accurately is important.
||Store below 30°C (room temperature) away from light. Once broached, the product must be used within six months.
||Norbrook Laboratories Australia P/L