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|Drug Name and Strength||Aminophylline 100mg|
|Indication||A bronchodilator in the adjunctive treatment of heart failure, especially where there is concurrent chronic obstructive lung disease in small breeds of dogs; acute pulmonary oedema with bronchospasm; cardiac asthma; chronic bronchitis accompanying mitral disease.|
|Contraindications||Pregnancy, tachydysrhythmias, gastrointestinal ulcers.|
|Actions||Theophylline is one of the naturally occurring alkaloids of the xanthine group. Aminophylline is a soluble double salt of theophylline and ethylene diamine and this improves the solubility of the latter by about 20 times. This ensures a more reliable absorption of theophylline from the gastrointestinal tract and more predictable effect. Aminophylline promotes diuresis by its action on the renal tubules which involves an increase in the rate of sodium and chloride excretion; this effect is considered weak. It dilates the bronchioles but, unlike other bronchodilators, it strengthens the force of contraction of the myocardium and the muscles of respiration with a corresponding decrease in the work associated with breathing. It inhibits mast cell degranulation and thus mediator release, increases mucociliary clearance and prevents microvascular leakage. It has a slight stimulant action on the cerebrum.|
|Precautions||Congestive heart failure, hepatic disease, hyperthyroidism, diabetes mellitus. Levels are increased by cimetidine, erythromycin and propranolol.|
|Dosage and Administration||Dogs, cats. 100 mg/10 kg or 200 mg/20 kg two to four times daily.|
|Storage||Store below 30°C (room temperature). Replace lid tightly after use.|
|MSDS (external link)||Aminyllin Tablets 100mg MSDS|
|Label (external link)||Aminyllin Tablets 100mg Label|
|Manufacturer||Mavlab Pty Ltd|