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|Drug Name and Strength||50mg Doxycycline|
|Indication||Treatment of bacterial infections caused by organisms sensitive to doxycycline in dogs and cats, including infections of the skin, upper and lower respiratory tract, genitourinary tract, middle ear, skeletal system and GI tract.|
|Contraindications||Administration in the last trimester of pregnancy or in neonatal animals (first month of life).|
|Actions||Doxycycline distributes rapidly and extensively in the body. It enters almost all tissues and body fluids; high concentrations are found in the kidneys, liver, bile, lungs, spleen and bone. Lower concentrations are found in serosal fluids, synovia, ascitic fluid, prostatic fluid, and vitreous humor.All tetracyclines tend to chelate calcium ions, but less so for doxycycline. They are deposited irreversibly in the growing bones and in dentin and enamel of unerupted teeth of young animals, or even the foetus if transplacental passage occurs. Drug bound in this fashion is pharmacologically inactive. Plasma half-life is five hours (cats) to around 10 hours (dogs).Doxycycline is 90% bound to plasma proteins. Up to 40% of doxycycline is metabolised in the liver, and excretion is via the kidney (by glomerular filtration, some in active form), and the gastrointestinal (GI) tract (via intestinal cells, and directly). There is also notable excretion in milk, saliva and tears. Doxycycline is the least damaging of all the tetracyclines in its potential for nephrotoxicity. Large doses of any of the tetracyclines can induce significant hepatotoxic effects.Doxycycline can be administered with food and is not affected by milk as are other tetracyclines. It may be partially bound by antacids, kaolin and iron preparations, however.Microbiology Doxycycline is an advanced analogue of the tetracycline class of antibiotics, and is a broad spectrum antibiotic for use in small dogs and cats. As a member of the tetracycline family, doxycycline interferes with protein synthesis of susceptible organisms including Staphylococcus sp., Streptococcus sp., Escherichia coli, Pasteurella sp., Haemophilus sp., Clostridia sp., Listeria sp., Bordetella sp., Klebsiella sp., Bacteriodes sp., Rickettsia sp., Mycoplasma sp. and Chlamydia sp.Pharmacokinetics Tetracycline antimicrobials inhibit protein synthesis by binding to the 30S subunit of the ribosome, interfering with RNA-protein translation. Thus tetracyclines exhibit both bacteriostatic and bactericidal activity, depending on the bacteria and the dose. Doxycycline has a broader spectrum than many tetracyclines because it is more lipophilic, leading to higher tissue penetration and greater volume of distribution, including the blood-brain barrier, where cerebrospinal fluid concentrations reach about 30% of the plasma concentrations.|
|Precautions||The use of tetracyclines in young animals before eruption of adult teeth may lead to permanent yellow discolouration of the teeth.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.|
|Dosage and Administration||Loading dose. Give 5 mg/kg, followed by two doses of 2.5 mg/kg at 12 hourly intervals. Maintenance dose. Give 2.5 mg/kg once daily.Tablets should be administered in conjunction with or immediately after feeding. Duration of therapy should be for five to seven days or for 48 hours after clinical signs have subsided. Longer duration of therapy is recommended for chronic or refractory conditions. As a guide, the following durations of therapy are recommended: chronic skin disease: 10 to 20 days; chronic cystitis: 10 to 20 days; respiratory disease: eight to 10 days.|
|Storage||Store below 30°C (room temperature).|
|MSDS (external link)||Doxycycline Tablets 50mg MSDS|
|Label (external link)||Doxycycline Tablets 50mg Label|
|Manufacturer||Apex Laboratories Pty Ltd|