Apex Ear Drops 15ml

Polymyxin B sulfate 10,000 IU,
Nitrofurazone 2.6 mg,
Pyrethrins 0.5 mg,
Neomycin sulfate 5 mg,
Lignocaine hydrochloride 2.5 mg

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More Information
Drug Name and Strength Polymyxin B sulfate 10,000 IU,
Nitrofurazone 2.6 mg,
Pyrethrins 0.5 mg,
Neomycin sulfate 5 mg,
Lignocaine hydrochloride 2.5 mg
Quantity 15ml Bottle
Indication Bacterial and parasitic external auditory meatus infections in cats and dogs.
Actions Apex ear drops are antibacterial and insecticidal. They penetrate and release wax. Pyrethrins are effective against ear mites and are amongst the safest ectoparasiticides available. These drops also contain a local anaesthetic for immediate relief.Microbiology Polymyxin B sulfate is a polypeptide bactericidal antibiotic that exerts its effect by interacting strongly with the bacterial cell membranes radically disrupting their permeability and function. It is more effective against Gram-negative than Gram-positive bacteria and its narrow spectrum of activity includes Enterobacter, Klebsiella, Salmonella, Pasteurella, Bordetella and Shigella species, and Escherichia coli. In vitro synergism has been demonstrated with neomycin against Salmonella. The effectiveness of polymyxin B is markedly reduced in the presence of pus and anionic detergents, so it is important to clean the ear canal prior to administration of the drops. Neomycin sulfate is an aminoglycoside antibiotic limited to topical use. It is effective against rapidly dividing bacteria and only needs a short contact time to exert its effect. It has a broad spectrum of activity that includes E. coli, Proteus, Actinobacillus, Salmonella and Klebsiella. Nitrofurazone is a safe and effective antimicrobial that is bacteriostatic at low doses and bactericidal at high doses. The basic mechanism of action has not been determined; however, it is thought to exert its effect by inhibiting a number of microbial enzyme systems including those involved in carbohydrate metabolism. Its spectrum of activity includes Staphylococcus aureus and Streptococci.
Precautions Do not use if the tympanic membrane is not intact.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.
Dosage and Administration Instil 10 to 15 drops into the ear once or twice daily or as directed by a veterinary surgeon.Shake well before using.
Storage Store below 25°C (air conditioning).
MSDS (external link) Apex Ear Drops 15ml MSDS
Label (external link) Apex Ear Drops 15ml Label
Manufacturer Apex Laboratories Pty Ltd
Refrigerated Product No
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