Arthropen Vet 100 10ml x 12

Pentosan polysulfate sodium 100 mg/mL

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More Information
Drug Name and Strength Pentosan polysulfate sodium 100 mg/mL
Quantity 12x 10ml Bottles
Indication An aid in the treatment of noninfectious inflammatory joint disease in dogs and horses. Osteoarthritis, especially conditions affecting multiple joints; osteochondrosis dissecans; traumatic joint and periarticular inflammation in dogs and horses.
Contraindications Do not use in animals with clotting defects, traumatic haemorrhage, infection or liver or kidney failure.
Actions Pentosan polysulfate is a semisynthetic polysaccharide polymer that possesses anti-inflammatory, antiarthritic and chondroprotective properties. These beneficial effects arise from direct anti-inflammatory activity; inhibition of neutrophil migration into joints; stimulation of hyaluronic acid synthesis by synovial fibroblasts which results in a marked increase in synovial volume and viscosity; stimulation of chondrocytes and the biosynthesis of proteoglycans; strong fibrinolytic activity which improves the circulation of subchondral bone and periarticular structures.
Precautions Any blood vessel, even a small one, will bleed more freely and for longer if a track of pentosan polysulfate is left as the needle is withdrawn. Hence the advice that, when injected intra-articularly, the needle should be ‘washed’ with joint fluid before withdrawal.
Dosage and Administration Injection method with a 21 gauge needle: administer in dogs by intramuscular or subcutaneous injection. Administer in horses by intra-articular or intramuscular injection.Horses. Intra-articular injection. 120 to 240 mg. Dosage should be adapted to the volume of the joint space and the severity of the condition being treated. Usually a 240 mg (2.4 mL) dose is appropriate for a carpal joint and a 120 mg (1.2 mL) dose is suitable for a fetlock joint. Injections should be repeated once weekly for three to four injections. More than one joint may be treated at a time. Prepare the site as for surgery, avoiding iodine based skin preparations. Use a neutral, soapless skin cleanser. Prepare vial seal and withdraw chosen dosage aseptically into a sterile syringe. A 22 gauge non-cutting needle is suitable for injection. Introduce into the joint space with steady even pressure. Allow approximately 1 to 2 mL of synovial fluid to escape according to the intended dosage volume. Draw back once or twice and mix Arthropen Vet Injection and the joint fluid within the joint. Apply a firm elastic bandage around the joint for three to four hours after injection. Intramuscular injection. 3 mg/kg on four occasions with an interval of five to seven days between injections.Dogs. Intramuscular or subcutaneous injection. 3 mg/kg on four occasions with an interval of five to seven days between injections.
Storage Protect from light. Shelf life: 36 months.
MSDS (external link) Not specified
Label (external link) Not specified
Manufacturer Randlab Australia Pty Ltd
Refrigerated Product No
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