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|Drug Name and Strength||Cyclosporin 100mg/ml|
|Indication||Treatment of chronic manifestations of allergic dermatitis in cats, which can have various manifestations, including eosinophilic plaques, head and neck excoriation, symmetrical alopecia and/or miliary dermatitis. Clinical signs of allergic dermatitis such as pruritus and skin inflammation are not specific for this disease. Other causes of dermatitis such as ectoparasitic infestations should be evaluated and eliminated. It is good practice to treat flea infestations before and during treatment of allergic dermatitis. A complete clinical examination should be performed prior to treatment. The immune status of the cats to FeLV and FIV infections should be assessed before treatment.|
|Contraindications||Do not administer to cats infected with FeLV or FIV, with a history of malignant disorders or progressive malignant disorders, aged less than 6 months, or weighing less than 2.3 kg.|
|Actions||Cyclosporin is a selective immunomodulator that acts on T-lymphocytes. It exerts anti-inflammatory and antipruritic effects in the treatment of allergic dermatitis. It acts specifically and reversibly on the cellular immune reaction by inhibiting resting T-lymphocytes and the antigen triggered release of lymphokines by activated T-cells. It also inhibits eosinophil recruitment and activation, keratinocyte cytokine production, Langerhans cell functions, degranulation of mastocytes, and therefore inhibits release of histamine and proinflammatory cytokines. It does not depress haematopoiesis and has no effect on the function of phagocytic cells.|
|Precautions||The safety of the drug has not been studied in male reproducing cats or in pregnant or lactating female cats. Cyclosporin was teratogenic in laboratory animals at maternally toxic doses but no teratogenic effects were observed in the well tolerated dose range. In laboratory animals, cyclosporin crosses the placental barrier and is excreted via milk. A thorough risk–benefit analysis should be undertaken before using in reproducing, pregnant or lactating cats.Cyclosporin may cause elevated levels of blood glucose. The effect of cyclosporin in cats with diabetes has not been evaluated. Cyclosporin should be used with caution in cats with diabetes mellitus.While cyclosporin does not induce tumours, it does inhibit T-lymphocytes and therefore treatment with cyclosporin may lead to an increased incidence of clinically apparent malignancy. If lymphadenopathy is observed in cats being treated with cyclosporin, further clinical investigations are recommended and treatment discontinued if necessary.Cats that are seronegative for Toxoplasma gondii may be at risk of developing clinical toxoplasmosis if they become infected while under treatment. In rare cases this can be fatal. Potential exposure of seronegative cats to Toxoplasma should therefore be minimised (e.g. keep indoors, avoid raw meat or scavenging). Cyclosporin was shown to not increase T. gondii oocyte shedding in a controlled laboratory study. In cases of clinical toxoplasmosis or other serious systemic illness, stop treatment with cyclosporin and initiate appropriate therapy.As cyclosporin is immunosuppressive, any infections should be properly treated before initiation of treatment. Infections occurring during treatment are not necessarily a reason for drug withdrawal, unless the infection is severe. It is not recommended to use other immunosuppressive agents concomitantly.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.|
|Dosage and Administration||The recommended dose of cyclosporin is 7 mg/kg bodyweight (Atopica Oral Solution 0.07 mL/kg). Atopica Oral Solution can be given either mixed with food or directly into the mouth. If given with food, the solution should be mixed with a small amount of food, preferably after a sufficient period of fasting to ensure complete consumption by the cat. When given directly into the mouth with the syringe, insert the syringe directly into the cat's mouth and deliver the entire dose.Atopica Oral Solution should initially be given daily until a satisfactory clinical improvement is seen, usually within four to eight weeks. Cats should be regularly re-evaluated and treatment options reviewed.Once the clinical signs of allergic dermatitis are satisfactorily controlled, the product can then be given every second day. In some cases where the clinical signs are controlled with every second day dosing, the veterinarian can give Atopica every three to four days. Treatment may be stopped when the clinical signs are controlled. On recurrence of clinical signs, treatment should be resumed at daily dosing, and in certain cases, repeated treatment courses may be required.|
|Storage||Store below 30°C (room temperature). Do not store below 15°C. Do not refrigerate. Use the contents within 10 weeks of first broaching of the vial. Discard the unused portion.|
|MSDS (external link)||Atopica Capsules 10mg Green MSDS|
|Label (external link)||Atopica Capsules 10mg Green Label|
|Manufacturer||Elanco Animal Health|