This is a prescription medicine. Please ensure that you have read the "How to Order" page before ordering this item.
After first use, opened vials may be stored below 25°C (Air conditioning) for 6 weeks. Discard any unused portion after 6 weeks. As we cannot guarantee the conditions during transit, we strongly recommend ordering less than 6 weeks worth of medication at a time. Please read our shipping information and terms and conditions closely as we will not be liable if your medications do not arrive cold.
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|Drug Name and Strength||An aqueous suspension of insulin containing 40 IU/mL of highly purified porcine insulin, 35% as amorphous zinc insulin and 65% as crystalline zinc insulin|
|Indication||Diabetes mellitus in dogs and cats.|
|Contraindications||Do not use in food producing species of animals.|
|Actions||An insulin product with intermediate length of action. It contains porcine insulin, which is structurally identical to canine insulin. In cases of insulin deficiency and/or decreased insulin sensitivity, the required blood levels can be achieved by using an individually adjusted dose of Caninsulin.|
|Precautions||It is important to establish a strict feeding schedule with a minimum of fluctuations and changes in consultation with the owner. Stress and irregular exercise must be avoided. Care must be taken with the use of corticosteroids. The use of progestogens (oestrus inhibitors) in patients suffering from diabetes mellitus should be avoided. Ovariohysterectomy should be considered. Caninsulin is not recommended for the initial treatment of animals presented with diabetic ketoacidosis. Hypoglycaemia is a potential sequel to insulin use. It is recommended that the owner is provided with strategies to prevent, recognise and respond to hypoglycaemia.Disposal Dispose of empty container by wrapping with paper and putting in garbage.|
|Dosage and Administration||It is recommended to administer Caninsulin using insulin syringes with 40 units/mL markings (U-40, 1 mL or 0.5 mL insulin syringes). Shake the vial thoroughly until a homogeneous, uniformly milky suspension is obtained. Foam on the surface of the suspension formed during shaking should be allowed to disperse before the product is used and, if required, the product should be gently mixed to obtain a homogeneous, uniformly milky suspension before use. Agglomerates can form in insulin suspensions: do not use the product if visible agglomerates persist after shaking thoroughly. Use all product within six weeks of withdrawing the first dose. Caninsulin can be administered by intramuscular or subcutaneous injection. The dose and frequency of administration depends on the degree of deficit in the animal's own insulin production and individual variations in metabolism leading to differences in the duration of activity. After an initial starting dose, the individual maintenance dose must be established by monitoring the animal's clinical response to insulin treatment, which usually includes interpretation of serial blood glucose curves and owner home monitoring records. The duration of activity of Caninsulin may be sufficient to achieve acceptable clinical control in some dogs with once daily administration. All other dogs will need to be treated with twice daily administration. The duration of action in cats is shorter than in dogs. All cats should be started on twice daily Caninsulin administration.Twice daily Caninsulin administration. (Cats and dogs.) The starting dose is 0.25 to 0.5 IU/kg bodyweight twice daily, rounded down to the nearest whole unit (based on the animal's fasting blood glucose measurement prior to starting therapy). Blood glucose concentration < 20 mmol/L or < 3.6 g/Ll (< 360 mg/dL). Caninsulin 0.25 IU/kg bodyweight twice daily. ≥ 20 mmol/L or ≥ 3.6 g/L (≥ 360 mg/dL). Caninsulin 0.5 IU/kg bodyweight twice daily. Obese cats and dogs. Use ideal bodyweight to calculate the initial insulin dose. The daily food ration should be divided into two equal parts. Composition and quantity of the daily food intake should be constant. Administer the Caninsulin dose every 12 hours and feed half of the daily food ration with each injection. Dose adjustments in dogs. Subsequent adjustment to establish the maintenance dose should be made by increasing or decreasing the daily dose by approximately 10%, according to the evolution of the diabetes clinical signs, and according to the results of serial blood glucose measurements. Alterations in dose should not normally be made more frequently than every one to three weeks. Dose adjustments in cats. Subsequent adjustment to establish the maintenance dose should be made by increasing or decreasing the daily dose according to the results of serial blood glucose measurements. Alterations in dose should not normally be made more frequently than every one to three weeks. Increments of 1 IU per injection are recommended. Ideally no more than 2 IU per injection should be administered in the first three weeks of treatment. Due to the day to day variation in the blood glucose response, and the variations in insulin responsiveness that are seen with time, larger or more frequent increases in dose are not recommended.Once daily Caninsulin administration. (Dogs only.) The initial daily dose is 0.5 IU/kg bodyweight once daily (rounded down to the nearest whole unit). The daily food ration should be divided into two equal parts. Composition and quantity of the daily food intake should be constant. Administer the Caninsulin dose with the first half of the daily ration and feed the second meal approximately 7.5 hours later (e.g. 08.30 and 16.00).Further dose adjustments should be made progressively as previously explained for dogs.|
|Storage||Store at 2 to 8°C. (Refrigerate. Do not freeze.) Protect from light. After first use, opened vials may be stored below 25°C (air conditioning) for six weeks. Discard any unused portion after six weeks.|
|MSDS (external link)||Caninsulin 10ml MSDS|
|Label (external link)||Caninsulin 10ml Label|
|Manufacturer||MSD Animal Health|