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|Drug Name and Strength||Pentosan polysulfate sodium 100 mg/mL|
|Indication||Relief of pain associated with noninfectious inflammatory joint disease in dogs and as an aid in the treatment of noninfectious inflammatory joint disease in horses: (i) osteoarthritis, especially in conditions affecting multiple joints; (ii) osteochondrosis dissecans; (iii) traumatic joint and peri-articular inflammation in working and racing dogs, and for the relief of lameness and pain in horses associated with osteoarthritis or traumatic joint disease; (iv) as treatment following intra-articular surgery, but not within the first 24 hours.|
|Contraindications||Administration to dogs with clotting defects, traumatic haemorrhage, infection, hepatic or renal failure.|
|Actions||Disease modifying osteoarthritis drug (DMOAD).Pharmacology The pharmacological activities of pentosan polysulfate considered responsible for disease modification in osteoarthritis include the following: direct anti-inflammatory activity; direct inhibition of enzymes implicated in cartilage destruction and activation of the bradykinin, complement and fibrinolytic systems (elastase, cathepsin B, hyaluronidase); indirect modulation of cartilage degradation by reduction in tissue levels of matrix metalloproteinases (MMP) concomitant with elevation of MMP inhibitor (TIMP); reduction in activity of tumour necrosis factor-α (TNF-α) at sites of inflammation; stimulation of fibrinolysis (via increased tissue plasminogen activator (tPA) and reduced tPA inhibitor) by capillary endothelium; stimulation of release of superoxide dismutase (SOD) by capillary endothelium; stimulation of hyaluronan synthesis by synovial fibroblasts; and stimulation of chondrocyte synthesis of proteoglycans and DNA.|
|Dosage and Administration||Dogs. Four 3 mg/kg (1.0 mL/33 kg) subcutaneous or intramuscular injections, with an interval of five to seven days between injections. Horses. Four 2 to 2.5 mg/kg (10 to 12.5 mL per 500 kg horse) intramuscular injections, with an interval of five to seven days between injections.|
|Storage||Store below 25°C (air conditioning.) Protect from light.|
|MSDS (external link)||Cartrophen Vet 10ml MSDS|
|Label (external link)||Cartrophen Vet 10ml Label|