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| Drug Name and Strength | Pentosan polysulfate sodium 100 mg/mL |
|---|---|
| Quantity | 10ml Bottle |
| Indication | Relief of pain associated with noninfectious inflammatory joint disease in dogs and as an aid in the treatment of noninfectious inflammatory joint disease in horses: (i) osteoarthritis, especially in conditions affecting multiple joints; (ii) osteochondrosis dissecans; (iii) traumatic joint and peri-articular inflammation in working and racing dogs, and for the relief of lameness and pain in horses associated with osteoarthritis or traumatic joint disease; (iv) as treatment following intra-articular surgery, but not within the first 24 hours. |
| Contraindications | Administration to dogs with clotting defects, traumatic haemorrhage, infection, hepatic or renal failure. |
| Actions | Disease modifying osteoarthritis drug (DMOAD).Pharmacology The pharmacological activities of pentosan polysulfate considered responsible for disease modification in osteoarthritis include the following: direct anti-inflammatory activity; direct inhibition of enzymes implicated in cartilage destruction and activation of the bradykinin, complement and fibrinolytic systems (elastase, cathepsin B, hyaluronidase); indirect modulation of cartilage degradation by reduction in tissue levels of matrix metalloproteinases (MMP) concomitant with elevation of MMP inhibitor (TIMP); reduction in activity of tumour necrosis factor-α (TNF-α) at sites of inflammation; stimulation of fibrinolysis (via increased tissue plasminogen activator (tPA) and reduced tPA inhibitor) by capillary endothelium; stimulation of release of superoxide dismutase (SOD) by capillary endothelium; stimulation of hyaluronan synthesis by synovial fibroblasts; and stimulation of chondrocyte synthesis of proteoglycans and DNA. |
| Dosage and Administration | Dogs. Four 3 mg/kg (1.0 mL/33 kg) subcutaneous or intramuscular injections, with an interval of five to seven days between injections. Horses. Four 2 to 2.5 mg/kg (10 to 12.5 mL per 500 kg horse) intramuscular injections, with an interval of five to seven days between injections. |
| Storage | Store below 25°C (air conditioning.) Protect from light. |
| MSDS (external link) | Cartrophen Vet 10ml MSDS |
| Label (external link) | Cartrophen Vet 10ml Label |
| Manufacturer | Not specified |
| Refrigerated Product | No |
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