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|Drug Name and Strength||Cephalexin 300mg|
|Indication||Treatment of infections in dogs and cats caused by cephalexin sensitive organisms, including infections of soft tissue, skin, respiratory tract, urinary tract, digestive tract and for the prevention and treatment of osteomyelitis.|
|Contraindications||Administration to animals with a history of allergic reactions to cephalosporins or other penicillins. Do not use in food producing animals.|
|Actions||Cephalexin is a broad spectrum cephalosporin antibiotic which is chemically related to penicillins. Because of its broad spectrum of activity, cephalexin makes an ideal choice for trauma cases where diffusion into bone and joints may be important. It provides a good treatment and prevention for osteomyelitis and supports the needs of surgical prophylaxis. In cases of persistent infections (pyodermas and abscesses) Cephaforte Tablets are ideal for long-term therapy.Microbiology As cephalexin is resistant to the action of β-lactamases, Cephaforte is therefore active against strains of Staphylococcus aureus that are insensitive to penicillin (or related antibiotics such as ampicillin or amoxycillin). Cephaforte Tablets have bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria, including Staphylococcus sp., Streptococcus sp., Corynebacterium sp., Pasteurella multocida, Escherichia coli, Proteus sp., Micrococcus sp. and Moraxella sp., causing death of bacterial cells through a diversity of biological and biochemical effects on the cell wall.Pharmacokinetics Cephaforte Tablets are acid stable and active when administered orally. They have an excellent absorption profile, with distribution through most body fluids and tissues including kidneys, lungs, joints, bone, soft tissues and biliary tract. Cephalexin is excreted unmetabolised in the urine, and so provides high and sustained antibiotic levels in cases of urinary tract infections (UTI), and such levels are minimally affected by the usual variations in urinary pH associated with UTIs. Removal of the active agent is primarily through glomerular filtration through the kidneys as well as some tubular secretion. The elimination half-life of cephalexin is about one to two hours in dogs and cats.|
|Precautions||Disposal Dispose of empty container by wrapping with paper and placing in garbage.|
|Dosage and Administration||Administer orally. Give 15 mg/kg bodyweight twice per day. In refractory cases, dose may be increased to 20 mg/kg twice daily. Duration of treatment is at least three days, but may be extended at the discretion of the veterinarian.|
|Storage||Store below 30°C (room temperature).|
|MSDS (external link)||Cephaforte Tabs 300mg MSDS|
|Label (external link)||Cephaforte Tabs 300mg Label|
|Manufacturer||Jurox Pty Limited|