Cepravin DC 32's
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|Drug Name and Strength||Cephalonium dihydrate 250 mg/3 g syringe|
|Indication||Sustained, broad spectrum control of and protection against mastitis causing bacteria (including penicillin resistant strains) in nonlactating dairy cattle.Recommended for dry cow therapy to treat existing subclinical infections, and to prevent new infections which occur during the dry period. Cepravin Dry Cow aids in the reduction of clinical mastitis and subclinical mastitis in the subsequent lactation.|
|Contraindications||Administration to lactating cows.|
|Actions||Cepravin is formulated to provide effective antibiotic levels in the dry udder, and will maintain them for a period of up to ten weeks, including the critical precalving period.Cephalonium is a broad spectrum cephalosporin antibiotic which has bactericidal activity against the majority of organisms associated with bovine mastitis. This antibiotic possesses a significant advantage over the penicillins in that it resists penicillinase and thus has a spectrum of activity that includes Gram-negative organisms. Cephalonium is active against Staphylococcus aureus, including penicillin-resistant strains, Streptococcus agalactiae, Strep. dysgalactiae, Strep. uberis, Escherichia coli, Corynebacterium pyogenes and C. ulcerans. The antibiotic is also active against other organisms recovered from the bovine udder, including Proteus sp., Klebsiella sp., Citrobacter sp. and Enterobacter strains. Cephalonium is a β-lactam that acts by inhibiting the enzyme transpeptidase which is involved in the final cross linking stage of peptidoglycan synthesis. Peptidoglycan is a heteropolymeric component of the bacterial cell wall. Inhibition of bacterial cell wall synthesis during reproduction results in vulnerable forms of bacteria which subsequently lyse. The antibacterial activity is not impaired in the presence of milk.|
|Precautions||Do not use in lactating cows. Use only at the time of drying off. Do not use in cows with a dry period of less than seven weeks (see Withholding Periods).Wear rubber gloves when infusing this treatment.|
|Dosage and Administration||The contents of 1 syringe should be infused into the teat canal of each quarter immediately after the last milking of the lactation. Before infusion, the teat should be thoroughly cleaned and disinfected. Care should be taken to avoid contamination of the syringe nozzle after the protective cap has been removed. After infusion, it is advisable to dip the teats in an antiseptic preparation specifically designed for this purpose.It is particularly important during the first few days following infusion that the cow should not be encouraged to ‘let down’ her milk as antibiotic may be lost. It is advisable, therefore, to keep recently dried off cows away from the milking shed to avoid stimulating the ‘let down’ reflex.|
|Storage||Store below 30°C (room temperature). Protect from light. Store in the closed original container in a well ventilated area.|
|MSDS (external link)||Cepravin Dc 20's MSDS|
|Label (external link)||Cepravin Dc 20's Label|
|Manufacturer||MSD Animal Health|