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|Drug Name and Strength||Clomipramine hydrochloride 5mg|
|Indication||Treatment of stereotypic behaviours (obsessive–compulsive disorders) in dogs such as acral lick dermatitis, excessive grooming and tail chasing. Aid in the treatment of anxiety disorders such as destructiveness, excessive vocalisation and loss of toilet control, associated with separation anxiety, and in the treatment of urine spraying in desexed and female cats (5 mg tablet) in combination with behavioural modification.|
|Actions||Clomipramine and its major metabolite, desmethylclomipramine, act in vivo to block the neuronal reuptake of noradrenaline and serotonin (5-HT). In this way, the broad spectrum activity of Clomav Tablets combines the properties of a tricyclic antidepressant and a serotonin reuptake inhibitor.|
|Precautions||From the known mechanism of action, it is recommended to use Clomav Tablets with care in dogs or cats with cardiac arrhythmias, epilepsy or narrow angle glaucoma. Due to the potential for anticholinergic effects, Clomav Tablets should also be used with care in dogs and cats with a known predisposition to developing urinary tract obstruction or urinary retention. Clomav Tablets are not recommended for treatment of aggression, or for treating a dog or cat for the above indicated behaviours where that animal has a history or predisposition to aggressive behaviour. The efficacy and safety of clomipramine hydrochloride tablets has not been established in dogs and cats weighing less than 1.25 kg or less than six months of age. Clomipramine hydrochloride is metabolised by hepatic glucuronidation and as cats use this pathway less efficiently than dogs, special care must be taken when prescribing Clomav 5 mg Tablets to cats. Use during pregnancy and lactation. The safety of clomipramine hydrochloride tablets has not been established in breeding or lactating dogs or cats. Clomav Tablets are recommended for use in breeding dogs and cats only if the benefit:risk ratio is considered justified by the veterinarian.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126. Additional first aid information. In children, accidental ingestion should be regarded as serious. There is no specific antidote. In case of accidental ingestion, seek medical advice immediately and show the product label.Disposal Dispose of empty container by wrapping with paper and putting in the garbage.|
|Dosage and Administration||Clomav Tablets should be given orally, preferably with food.Dogs. Clomav Tablets should be administered twice daily at a dose rate of 1 to 2 mg clomipramine hydrochloride/kg bodyweight to give a total daily dose of 2 to 4 mg/kg. In clinical trials, clomipramine hydrochloride tablets administered for two to three months in combination with appropriate behaviour modification techniques has been shown to favourably enhance and accelerate the response to behaviour modification in the treatment of anxiety disorders in dogs (generalised anxiety and anxiety when separated from the owner). Clomipramine has been shown to also be effective in the treatment of stereotypic behaviours when administered for a minimum of 1 month. 1.25 to 2.5 kg bodyweight. Give half a Clomav 5 mg tablet twice daily. 2.5 to 5 kg. Give 1 Clomav 5 mg tablet twice daily. 5 to 10 kg. Give half a Clomav 20 mg tablet twice daily. 10 to 20 kg. Give 1 Clomav 20 mg tablet twice daily. 20 to 40 kg. Give half a Clomav 80 mg tablet twice daily. 40 to 80 kg. Give 1 Clomav 80 mg tablet twice daily.Cats. Clomav Tablets should be administered once daily at a rate of 0.3 to 1 mg clomipramine hydrochloride/kg bodyweight. If the cat appears sedated, the lower end of the dose range can be used. 3 to 6 kg bodyweight. Give half a Clomav 5 mg tablet once daily. 6 to 12 kg. Give 1 Clomav 5 mg tablet once daily.Tailing off. It may be advisable to 'tail off' or gradually reduce the dose of clomipramine at the end of a course of treatment.|
|Storage||Store below 30°C (room temperature). Protect from moisture, heat and light. Keep container tightly closed.|
|MSDS (external link)||Clomav Tablets 5mg MSDS|
|Label (external link)||Clomav Tablets 5mg Label|
|Manufacturer||Mavlab Pty Ltd|