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| Drug Name and Strength | Tulathromycin 100mg/ml |
|---|---|
| Quantity | 100ml Bottle |
| Indication | Cattle. Treatment of bovine respiratory disease associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis sensitive to tulathromycin. Pigs. Treatment of swine respiratory disease associated with Pasteurella multocida, Mycoplasma hyopneumoniae and Haemophilus parasuis sensitive to tulathromycin. |
| Actions | Microbiology Tulathromycin has in vitro activity against Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, and Haemophilus somnus (Histophilus somni), the bacterial pathogens most commonly associated with bovine respiratory disease, and against Actinobacillus pleuropneumoniae, Pasteurella multocida and Mycoplasma hyopneumoniae, the bacterial pathogens most commonly associated with swine respiratory disease.Pharmacology Tulathromycin is a semisynthetic macrolide antimicrobial agent. It differs from many other macrolides in that it has a long duration of action that is, in part, due to its three amine groups, therefore it has been given the chemical subclass designation of triamilide. Macrolides are bacteriostatic acting antibiotics and inhibit essential protein biosynthesis by virtue of their selective binding to bacterial ribosomal RNA. They act by stimulating the dissociation of peptidyl-tRNA from the ribosome during the translocation process.Pharmacokinetics In cattle and pigs, the pharmacokinetic profile of tulathromycin, when administered as a single subcutaneous dose of 2.5 mg/kg bodyweight, is characterised by rapid and extensive absorption, followed by wide tissue distribution and slow elimination. Tulathromycin concentrations in lung homogenate are considerably higher than those in plasma. There is strong evidence of substantial accumulation of tulathromycin in neutrophils and alveolar macrophages. Peak concentrations are followed by a slow decline in systemic exposure with an apparent elimination half-life of 90 and 91 hours in plasma in cattle and pigs respectively. |
| Precautions | Any variation by the prescribing veterinarian to the approved dose, frequency, duration, route, disease or target species may result in the need to extend the approved withholding period.Avoid using the product simultaneously with other macrolides or lincosamides.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126. If accidental eye exposure occurs, flush the eyes immediately with clean water. If accidental skin exposure occurs, wash the skin immediately with soap and water. In case of accidental self-injection, seek medical advice immediately and show the package insert or the label to the doctor.Disposal Dispose of empty containers by wrapping with paper and putting in garbage. |
| Dosage and Administration | Cattle. 1 mL/40 kg bodyweight (tulathromycin 2.5 mg/kg) by a single subcutaneous injection high on the neck. Cattle > 400 kg bodyweight. Divide the dose so that no more than 10 mL are injected at one site. Re-treatment interval. Do not re-treat cattle for 12 weeks after last treatment. Do not re-treat dairy heifers.Pigs. 1 mL/40 kg bodyweight (tulathromycin 2.5 mg/kg) by a single intramuscular injection in the neck. Pigs > 100 kg bodyweight. Divide the dose so that no more than 2.5 mL are injected at one site. Retreatment interval. Do not re-treat pigs for eight weeks after last treatment. |
| Storage | Store below 30°C (room temperature). In use shelf life: use within 28 days of broaching the vial. |
| MSDS (external link) | Draxxin 100ml MSDS |
| Label (external link) | Draxxin 100ml Label |
| Manufacturer | Zoetis Australia Pty Ltd |
| Refrigerated Product | No |
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