Flusapex 40mg Tablets (per tablet)

98% of 100
Frusemide 40mg

Compatible file extensions to upload: pdf, png, jpg, jpeg

We will aim to dispatch this product within 24 hours.

Call us now for more info about our products on 1300 132 498.

Please choose wisely as we cannot refund prescription medicines.

Buy this product and earn special loyalty points!

This is a prescription medicine. A prescription is required from your veterinarian before we can supply this product. Please ensure that you have read the "How to Order" page before ordering this item.

All of our products are APVMA or TGA approved and identical to those used by your veterinarian. Please call or email us if you have any queries about any of the products on our site.

More Information
Drug Name and Strength Frusemide 40mg
Quantity 1 Tablet
Indication Aid in the treatment of oedema in dogs and cats, including oedema associated with congestive heart failure, pulmonary oedema and localised oedema associated with trauma or surgery.
Contraindications Administration to animals with evidence of impaired renal or hepatic function, or when neomycin is being administered.
Actions Frusemide inhibits the ability of the kidney to concentrate and dilute urine appropriately. Known as a loop diuretic, frusemide effectively removes fluid from tissues. It is used in a variety of conditions including congestive heart failure, pulmonary oedema, liver and kidney disease, some conditions associated with high blood pressure, and localised oedema.The net effect of frusemide administration is an increase in water, sodium, chloride, potassium, calcium, magnesium, hydrogen, ammonium and bicarbonate excretion and increased renin secretion. Frusemide also generally increases and redistributes the total renal blood flow. Extrarenally, frusemide administration leads to increased venous compliance and a decrease in right atrial pressure, pulmonary artery pressure, pulmonary artery wedge pressure and pulmonary blood volume. The effects on blood flow, both renally and extrarenally, appear to be related to prostaglandins, and these effects are dependent on normal prostaglandin production and blood volumes.Frusemide is absorbed mostly from the upper gastrointestinal tract and oral bioavailability can be variable. It can be up to 99% protein bound, which limits glomerular filtration of the medicine. Fifty to 60% of the medicine is excreted unchanged in urine and the remainder is conjugated to glucuronic acid in the kidney, liver or extrahepatic sites.Frusemide is actively excreted into the kidney tubular lumen and produces natriuresis and diuresis. Natriuresis is most pronounced only on the first dose. Frusemide is not categorised as a potassium sparing diuretic.Plasma half-life is biphasic, with a terminal half-life of 1.5 hours. Half-life is prolonged with renal insufficiency and it binds to excessive albumin in the urine, requiring dosing instructions to be adjusted in these situations.As well as natriuresis and diuresis, frusemide also increases venous compliance and decreases right atrial pressure, pulmonary arterial pressure and pulmonary arterial volume. Frusemide appears to enhance prostaglandin formation, potentially resulting in increase in systemic venous capacitance and subsequent decrease in left ventricular filling pressure. This effect appears to be dependent on a functioning kidney and uninhibited prostaglandin production.Frusemide is Pregnancy Category C: can affect the fetus, use only if the benefits outweigh the risks. Frusemide is also excreted into breast milk. Frusemide can be given with food.
Warnings Nonsteroidal anti-inflammatory drugs block the action of frusemide.
Precautions Monitor electrolyte balance with prolonged use. Tolerance to the effects of frusemide in long-term use has been described.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.
Dosage and Administration Small animals. 1 tablet/8 kg bodyweight daily. Large animals. 5 mg/kg bodyweight daily.
Storage Store below 25°C (air conditioning).
MSDS (external link) Flusapex Tablets 40mg MSDS
Label (external link) Flusapex Tablets 40mg Label
Manufacturer Apex Laboratories Pty Ltd
Refrigerated Product No
Write Your Own Review
Only registered users can write reviews. Please Sign in or create an account


Last refrigerated shipping date:
Monday 11th April

Re-commence refrigerated shipping date:
Tuesday 26th April

We are closed:

  • 15th April (Easter Friday)
  • 18th April (Easter Monday)
  • 25th April (Anzac Day)

We recommend taking a stock take of your pet supplies and placing your orders as soon as possible to avoid delays during this time.

Have a great Easter break