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|Drug Name and Strength||Dinoprost 5mg/ml|
|Indication||Cattle. Oestrus and ovulation. To more effectively control the time of oestrus cycling cattle. Individual cows or heifers treated during dioestrus will normally return to oestrus and ovulate within two to four days after treatment. (Note. Administration to cattle within four days after oestrus is unlikely to result in luteolysis of the corpus luteum. Administration within 48 hours before the onset of the next oestrus may not influence the timing of that oestrus after treatment.) Suboestrus or silent heat. Cattle with a functional corpus luteum but not expressing normal behavioural oestrus.Individual cattle may have normal cyclical ovarian activity without detectable behavioural oestrus; this occurs most frequently in the winter months, at peak lactation in high producing dairy cows, and in suckled beef cows. If a corpus luteum is present and ovulation has not occurred in the previous four to five days, administration will result in corpus luteum regression followed by return to oestrus and ovulation.Breeding of cattle treated with PGF2α for the above indication may be by natural service, artificial insemination at the usual time in relation to observed oestrus, or by fixed time insemination (78 hours or 72 and 96 hours post-treatment). Abortion. To induce abortion in cattle from five to 150 days gestation. Up to day 70, the interval from treatment to abortion is usually less than four days; between days 80 and 120, less than seven days; but beyond day 150, less than 60% may abort within three weeks even with doses of 35 mg or greater. Following abortion, foetal membranes may be retained. Death may result from ruptured uterus, especially if cervical dilatation does not occur. Parturition. To induce parturition on or after day 270 of gestation in cattle. The interval from administration to parturition is one to eight days (average three days). Induction of parturition in cattle is indicated where there is risk of oversize calves or where early parturition is desired. In addition, induction is indicated where pregnacies are complicated by miscellaneous conditions, e.g. mummified or macerated foetuses, hydrops amnii and hydroallantois. Use is indicated for expulsion of a dead foetus. Controlled breeding. Indicated for its luteolytic effect in cattle which can be utilised to control the timing of oestrus in oestrus cycling cattle that have a corpus luteum. The identified activity of Lutalyse permits a wide range of oestrus control programs for normally cycling animals, at least 35 days after calving.Horses. Oestrus and ovulation in cycling animals. Control the time of oestrus and ovulation in oestrus cycling horses.Mares treated with Lutalyse during dioestrus return to oestrus within two to four days in most cases and ovulate eight to twelve days after treatment. (Note. Administration to horses within four days after oestrus is unlikely to result in luteolysis of the corpus luteum. Administration within 48 hours before onset of the next oestrus may not influence the timing of that oestrus after treatment.) Horses difficult to breed. In extended dioestrus there is failure to exhibit regular oestrous cycles which is different from true anoestrus. Many mares described as anoestrus during the breeding season have serum progesterone levels consistent with the presence of a functional corpus luteum. A proportion of ‘barren’ maiden and lactating mares do not exhibit regular oestrus cycles and may be in extended dioestrus. Following abortion, early foetal death and resorption, or as a result of pseudopregnancy, there may be serum progesterone levels consistent with a functional corpus luteum. Treatment of such mares usually results in regression of the corpus luteum followed by oestrus and/or ovulation. Abortion. May be used to terminate pregnancy in mares through its luteolytic effect during those stages of pregnancy in which the corpus luteum is sensitive to its action and in which maintenance of pregnancy is dependent upon the corpus luteum as the sole source of progesterone.Up to day 35 of pregnancy luteal regression with Lutalyse will induce abortion; response to treatment between days 40 and 90 of gestation is less predictable possibly due to pregnant mare serum gonadotrophin (PMSG) secretion from the endometrial cups rendering the corpus luteum refractory to the luteolytic effects of PGF2α. Between days 90 and 120 of pregnancy, luteal regression may lead to abortion.Death may result from ruptured uterus, especially if cervical dilation does not occur.Swine. Parturition. To induce parturition in swine Lutalyse may be administered on day 111 to 113 (i.e. three days before farrowing). Response to treatment varies in individual animals with a mean interval from administration to parturition of approximately 33 hours. This can be advantageously employed to control the time of farrowing in sows and gilts in late gestation. Treatment earlier than three days prior to predicted farrowing date may produce weak piglets, resulting in reduced survival.|
|Contraindications||Swine. Administration to pregnant sows and gilts unless parturition is desired; intravenous administration; parturition induction earlier than 72 hours before predicted farrowing date may result in piglet death. Cattle, horses. Administration to pregnant animals unless parturition induction or abortion is desired; intravenous administration.|
|Actions||Prostaglandins occur in nearly all mammalian tissues. Prostaglandins (PG), especially E prostaglandins (PGEs) and F prostaglandins (PGFs), have been shown, in certain species, to increase (at time of parturition) in amniotic fluid, maternal placenta, myometrium, and blood; stimulate myometrial activity; and induce either abortion or parturition.Prostaglandins, especially PGF2α, have been shown to normally increase in the uterus and blood levels similar to those created by administration of doses of PGF2α which are luteolytic; be capable of crossing from the uterine vein to the ovarian artery (sheep); be related to IUD induced luteal regression (sheep); be capable of regressing the corpus luteum of most mammalian species studied to date.Prostaglandins have been reported to result in release of pituitary tropic hormones. Data suggest prostaglandins, especially PGEs and PGFs, may be involved in the process of ovulation and gamete transport. Also, PGF2α has been reported to cause increases in blood pressure, bronchoconstriction, and smooth muscle stimulation in certain species.|
|Warnings||Not for human use. Do not treat cattle and horses suffering from acute or subacute disorders of the vascular system, gastrointestinal tract, respiratory system or reproductive tract.|
|Precautions||Do not allow administration by pregnant women, persons with asthma or bronchial and other respiratory problems.First Aid If skin contact occurs, wash off immediately with soap and water. Instruction to physician. Treat respiratory distress resulting from accidental inhalation or injection of Lutalyse in humans with a rapid acting bronchodilator such as isoprenaline or salbutamol by inhalation.|
|Dosage and Administration||Swine. 2 mL within three days of predicted natural farrowing.Cattle. Nonpregnant. 5 mL intramuscularly. Pregnant. Doses required to induce abortion or parturition in cattle tend to be greater than doses required for luteolysis in nonpregnant cattle. For these indications effective dosages have ranged from 5 to 7 mL administered intramuscularly. Stage of gestation is an important factor influencing dose response. (For example, Lutalyse has been used successfully to induce abortion in cattle at up to 150 days gestation; however, even high doses of Lutalyse have been less effective during days 150 to 270.)Horses. Nonpregnant. Luteolytic in the mare at 1 mL administered intramuscularly.Lutalyse may be used to terminate pregnancy in mares through its luteolytic effect during those stages of pregnancy in which the corpus luteum is sensitive to its action and in which maintenance of pregnancy is dependent upon the corpus luteum as the sole source of progesterone. The clinical response to inducing abortion in horses may vary; repeat administration may be required.|
|Storage||Store below 30°C (room temperature).|
|MSDS (external link)||Lutalyse 100ml MSDS|
|Label (external link)||Lutalyse 100ml Label|
|Manufacturer||Zoetis Australia Pty Ltd|