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|Drug Name and Strength||Cyclosporin 2 mg/g|
|Indication||Treatment of idiopathic dry eye (chronic keratoconjunctivitis sicca [KCS]) and chronic superficial keratitis (CSK) in dogs.|
|Contraindications||Pre-existing viral or fungal ocular infections.|
|Actions||Cyclosporin has an immunomodulating effect, an anti-inflammatory effect and lacrimomimetic properties.|
|Precautions||Delay use until pre-existing viral or fungal ocular infections have been successfully treated.The safety of Optimmune in puppies, pregnant bitches or dogs used for breeding has not been determined.The clinical effect of Optimmune Ophthalmic Ointment has not been determined in dogs with KCS due to the following conditions: congenital alacrima, sulfonamide usage, canine distemper virus, metabolic disease, surgical removal of the third eyelid gland and facial nerve paralysis with loss of the palpebral reflex.Disposal Dispose of empty container by wrapping in paper and putting in garbage.|
|Dosage and Administration||Remove debris from affected eye(s) with a suitable nonirritating solution. Place the ointment directly on the cornea or into the conjuctival sac. Keratoconjunctivitis sicca. Apply a 6 mm strip of ointment to the affected eye(s) every twelve hours. Chronic superficial keratitis. Apply a 6 to 10 mm strip of ointment to the affected eye(s) every twelve hours.Continue treatment while condition persists. Dogs afflicted with KCS or CSK may require lifelong consistent therapy.For best results in treating KCS, the ointment should be administered early in the course of the disease before irreversible damage to the lacrimal tissue, or dense corneal scarring or pigmentation occurs. It is recommended that dogs exhibiting chronic recurring conjunctivitis be tested for adequate tear production.Several days to a few weeks of application may be required before the clinical effects of Optimmune are of sufficient magnitude to allow the safe withdrawal of previously initiated therapy.Abrupt withdrawal of a therapeutic agent immediately on initiation of treatment with Optimmune can result in rapid clinical relapse.|
|Storage||Store below 25°C (air conditioning).|
|MSDS (external link)||Optimmune MSDS|
|Label (external link)||Optimmune Label|
|Manufacturer||MSD Animal Health|