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|Drug Name and Strength||Phenylbutazone 200mg/mL|
|Indication||Musculoskeletal conditions and soft tissue swelling in horses requiring anti-inflammatory, antipyretic and analgesic effect, including acute joint and tendon synovitis, bursitis, acute sprains of joints and ligaments, sprains of tendons, serous arthritis, in conjunction with antibiotics in infective arthritis, soft tissue reaction following surgical procedures including castration, wound inflammation, tissue bruising and abrasions; pain associated with acute and chronic arthritic conditions, acute and chronic laminitis.|
|Contraindications||Severe cardiac, hepatic or renal disease. History of blood dyscrasias or gastrointestinal tract ulceration. Administration in conjunction with other drug therapy or within six weeks prior to or following therapy with coumarin anticoagulants.|
|Actions||Nonsteroidal anti-inflammatory, analgesic and antipyretic.Pharmacokinetics Studies on P-Butazone Paste indicate a plasma half-life of approximately 4.42 hours. Oral absorption of phenylbutazone can vary considerably between individual horses with up to tenfold differences in peak plasma concentrations. More consistent results can be obtained when the paste is administered prior to feeding. In most horses the considered minimal effective therapeutic plasma level of 7 microgram/mL should be maintained with adequate safety by administering the recommended dose rates at 12 hourly intervals during the acute stage of responsive conditions.|
|Precautions||Discontinue therapy if signs of lethargy, gastrointestinal tract irritation, inappetence, oral ulceration, or vascular disorders and hypoproteinaemia resulting in ventral abdominal oedema occur during treatment. Adhere strictly to dose rates recommended for ponies and foals, where there is a greater risk of toxicity than in the adult horse. See product literature for further details.|
|Dosage and Administration||Give orally via syringe 30 minutes prior to feeding. Horses. (450 kg) 10 mL twice on first day; then 5 mL twice daily for 4 days; then 5 mL daily or every alternate day, as required. Ponies. (225 kg) 5 mL daily for 4 days, then 2.5 mL daily or every alternate day as required.|
|Storage||Store below 30°C (room temperature).|
|MSDS (external link)||P Butazone Paste 230ml MSDS|
|Label (external link)||P Butazone Paste 230ml Label|
|Manufacturer||Virbac (Australia) Pty Limited|