Pentosan Equine 50ml
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|Drug Name and Strength||Pentosan polysulfate sodium 250 mg/mL|
|Indication||Noninfectious inflammatory joint disease, traumatic arthritis, degenerative cartilaginous joint disease, osteoarthritis and osteochondrosis dissecans in horses.|
|Contraindications||Administration to horses with clotting defects, traumatic haemorrhage, infection, renal or hepatic failure, or within two days of surgery.|
|Actions||Pharmacology Pentosan polysulfate is a semisynthetic polysaccharide polymer which possesses anti-inflammatory, antiarthritic and chondroprotective properties. These beneficial effects arise from direct anti-inflammatory activity; inhibition of neutrophil migration into joints; stimulation of hyaluronic acid synthesis by synovial fibroblasts which results in a marked increase in synovial fluid volume and viscosity; stimulation of chondrocytes and the biosynthesis of proteoglycans; and strong fibrinolytic activity which improves the circulation in subchondral bone and periarticular structures.|
|Dosage and Administration||Intramuscular. 3 mg/kg (one 6 mL vial/500 kg horse) by intramuscular injection on four occasions with an interval of five to seven days between injections. Intra-articular. 1 mL by intra-articular injection. Injections may be repeated once weekly for three to four injections. More than one joint may be treated at a time. Prepare site as for surgery. Avoid iodine based skin preparations. Use a neutral, soapless skin cleanser.A 20 gauge noncutting needle is suitable for injection. Introduce into the joint space with steady even pressure. Allow approximately 1.0 mL of synovial fluid to escape. Attach syringe of Pentosan Equine. Withdraw more synovial fluid into the syringe if possible and inject the joint fluid/Pentosan Equine mixture into the joint. Draw back once or twice and mix Pentosan Equine and the joint fluid within the joint. Note. Pentosan has anticoagulant properties. Any blood vessel, even a small one, will bleed more freely and for longer if a track of pentosan polysulfate is left as the needle is withdrawn, hence the advice that the needle be ‘washed’ with joint fluid before withdrawal from the joint.Blood is the most usual cause of sudden inflammatory swelling following intra-articular injection. Even small amounts may be reactive.Careful technique, avoiding tissue damage and subsequent firm bandaging for three to four hours will minimise risks of intra-articular haemorrhage.After intra-articular administration. Place a firm elastic bandage around the joint after injection and maintain the horse in a confined space for three to four hours. Remove bandage after that time.Rest the horse for two weeks following final injection and follow with a further two weeks of graded walking exercises before returning to work.|
|Storage||Store below 25°C (air conditioning). Do not freeze. Protect from light.|
|MSDS (external link)||Pentosan Equine 50ml MSDS|
|Label (external link)||Pentosan Equine 50ml Label|
|Manufacturer||Ceva Animal Health Pty Limited|