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| Drug Name and Strength | Reserpine 0.5mg/mL |
|---|---|
| Quantity | 20ml Bottle |
| Indication | Prolonged periods of calm sedation, e.g. as an adjunct to handling vicious or dangerously anxious horses. Where unfamiliar surroundings and unaccustomed stress produce anxiety in horses. A calming agent to aid in the training and education of horses. |
| Actions | Pharmacology Depletes catecholamine stores in the brain and in peripheral sympathetic nerve terminals. As a result, it has a calming and tranquillising action. It is not a hypnotic or narcotic, as are the promazine drugs. Serotonin, a regulatory amine, has a potent effect on the metabolism of the brain. High serotonin levels cause stimulation of cerebral activity and anxiety; lowered levels depress cerebral activity resulting in relaxation and calmness. Serotonin, on release from stores, undergoes rapid oxidative deamination, a metabolic process catalysed by monoamine oxidase. Reserpine causes a rapid release of serotonin from bound stores, which is rapidly metabolised by monoamine oxidase. The net depletion of serotonin which follows, brings about the calming and relaxing effects of Rakelin. Its effects continue for many days after administration. |
| Precautions | Rakelin may produce penile relaxation, therefore stallions should not be used to serve mares for 14 days after injection. |
| Dosage and Administration | Administer by intramuscular injection only. Individualise dosage; initial levels of serotonin stores will vary between animals. A brief period of diarrhoea accompanies the initial release of bound serotonin before its destruction by the action of monamine oxidase. Such a period of increased bowel activity is a reliable indicator that the desired response should follow. Adult horses. 1 to 4 mL weekly or as directed by a veterinary surgeon. Dosage must be sufficient to reduce amine stores. |
| Storage | Store below 25°C (air conditioning). Protect from light. |
| MSDS (external link) | Rakelin Injection MSDS |
| Label (external link) | Rakelin Injection Label |
| Manufacturer | Ceva Animal Health Pty Limited |
| Refrigerated Product | No |
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