Cepravin LC 20's
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|Drug Name and Strength||Cefuroxime sodium 250 mg/3 g syringe|
|Indication||Treatment of clinical mastitis in lactating cows. Provides broad spectrum control of mastitis causing bacteria (including penicillin resistant strains) in lactating dairy cattle.|
|Actions||Cepravin L.C. is an intramammary cerate containing cefuroxime in a quick-release oily base. The base disperses readily in milk and allows rapid distribution of high levels of the antibiotic in both milk and the tissues of the treated quarters.Cefuroxime is a second generation, semisynthetic cephalosporin antibiotic which is resistant to degradation by β-lactamase enzymes produced by both Gram-positive and Gram-negative pathogens. The following strains have been shown to be highly susceptible to cefuroxime and clinical mastitis involving these strains has been shown to respond to treatment with Cepravin L.C.: Staphylococcus sp., Staphylococcus aureus (including penicillin resistant strains), Streptococcus agalactiae, Strep. dysgalactiae, Strep. uberis, Escherichia coli, Enterobacter sp., Klebsiella sp., Citrobacter sp., Corynebacterium sp. (including Corynebacterium pyogenes), and Micrococcus sp.Cefuroxime is a β-lactam that acts by inhibiting the enzyme transpeptidase which is involved in the final cross linking stage of peptidoglycan synthesis. Peptidoglycan is a heteropolymeric component of the bacterial cell wall. Inhibition of bacterial cell wall synthesis during reproduction results in vulnerable forms of bacteria which subsequently lyse. Cepravin L.C. is therefore suitable for treatment of clinical mastitis caused by all the major mastitis pathogens.|
|Precautions||Milk for human consumption must not be taken from a cow during treatment (see Withholding Periods).Wear gloves when infusing this treatment.|
|Dosage and Administration||The contents of 1 syringe should be infused into the teat canal of the infected quarter every 12 hours, after each of three successive milkings.Before infusion, the teat should be thoroughly cleaned and disinfected. Care should be taken to avoid contamination of the syringe nozzle after the protective cap has been removed. After infusion, it is advisable to dip the teats in an antiseptic preparation specifically designed for this purpose.|
|Storage||Store below 30°C (room temperature) in the closed original container in a well ventilated area. Protect from light.|
|MSDS (external link)||Cepravin LC 20's MSDS|
|Label (external link)||Cepravin LC 20's Label|
|Manufacturer||MSD Animal Health|