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|Drug Name and Strength||Dexamethasone as sodium phosphate (1mg/mL) plus dexamethasone as phenylpropionate (2mg/mL)|
|Indication||Primary ketosis (acetonaemia), orthopaedic conditions (arthritis, bursitis, tenosynovitis, tendinitis, ligament and tendon sprains), shock, stress, allergic conditions and skin conditions (allergic dermatitis, burns, eczema and non-specific dermatoses).|
|Contraindications||Administration to animals with diabetes mellitus, osteoporosis, cardiac and renal diseases (but to a considerably reduced extent, as sodium retention and potassium loss are negligible at the recommended dosage). Unless abortion or early parturition is required, the use of Dexafort during the last trimester of pregnancy is contraindicated.|
|Actions||This preparation contains two highly active esters of dexamethasone which make it suitable for a wide range of conditions. Following intramuscular injection the short acting dexamethasone sodium phosphate produces rapid high blood sugar levels which are maintained for approximately 48 hours; the long acting ester dexamethasone phenylpropionate does not produce its maximum effect until 48 hours after injection but, once achieved, this effect is maintained for at least eight days. This combination of the two esters provides for both a rapid onset of activity and a prolonged duration of effect. The anti-inflammatory and antishock effect of the combination follows a similar pattern to the glucogenic effect.|
|Precautions||Corticosteroid therapy should be accompanied by effective antibiotic or sulfonamide therapy when infection is present. Since the activity of Dexafort persists for approximately eight days, any chemotherapy should be maintained for an appropriate period of time. Production in lactating animals may temporarily decline as with all corticosteroid treatment.As with all corticosteroid therapy, adrenal stimulation by ACTH is advisable if courses have been prolonged.|
|Dosage and Administration||Give by intramuscular or subcutaneous injection using normal aseptic techniques in all species. Horses, cattle. 10 mL. Foals, calves, sheep, goats, pigs. 1 to 3 mL. Dogs. 0.5 to 1 mL. Cats. 0.25 to 0.5 mL.|
|Storage||Store below 25°C (air conditioning). Protect from light.|
|MSDS (external link)||Dexafort MSDS|
|Label (external link)||Dexafort Label|
|Manufacturer||MSD Animal Health|