Key Inj 100ml
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|Drug Name and Strength||Ketoprofen 100 mg/mL|
|Indication||Nonsteroidal anti-inflammatory, analgesic and antipyretic for horses and cattle. Horses. Noninfectious inflammatory conditions of the musculoskeletal system, including traumatic arthritis/synovitis, tendinitis/desmitis, osteochondritis dissecans, osselets, laminitis, soft tissue swelling, and postsurgical inflammation and swelling.Ocular inflammatory conditions such as uveitis, keratitis and traumatic corneal ulceration.Alleviation of visceral pain in equine colic of various aetiologies. The analgesic effect manifests within 15 minutes of intravenous administration and increases over the following hour. Body temperature, pulse rate and respiratory rate decline during that time with respiratory rate reaching a minimum level at one hour after administration. Cattle. Noninfectious inflammatory conditions of the musculoskeletal system; may be a useful adjunct to specific treatment in the therapy of respiratory conditions, acute mastitis, mammary oedema and colic.|
|Contraindications||Administration to animals with severe renal or hepatic insufficiency; a history of gastrointestinal inflammatory disorders or ulceration; or a history of sensitivity to NSAIDs. Administration to animals less than 6 weeks old.|
|Actions||Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class. The anti-inflammatory, analgesic and antipyretic effects of ketoprofen are attributable to inhibition of the cyclooxygenase (COX) enzyme, which is responsible for the conversion of arachidonic acid into pro-inflammatory mediators.Pharmacokinetics Ketoprofen is readily and rapidly absorbed following intramuscular administration. It is widely distributed in tissues and substantial concentrations may be reached in synovial fluid. Ketoprofen has a half-life of one hour in the horse, and repeated administration does not result in drug accumulation in animals with normal renal and hepatic function. The elimination profile of ketoprofen contrasts with the dose dependent kinetics of phenylbutazone and the resultant accumulation and prolonged elimination following repeated dosage of phenylbutazone. Despite the short plasma half-life of ketoprofen, clinical effects are observed for several hours after administration, possibly due to delayed clearance from inflammatory fluid or a prolonged effect on inflammatory mediators. Ketoprofen is metabolised in the liver via conjugation with glucuronic acid and the glucuronic ester is excreted in the urine. The parent compound or its metabolites are detectable by conventional analytical methods in equine urine for up to 72 hours after intravenous administration of a therapeutic dose, and may be detectable by some techniques for up to ten days after treatment.In cattle, minimal ketoprofen passes into the mammary gland.|
|Precautions||Perivascular injection should be avoided. Safety of use in pregnant mares has not been determined.When Key Injection has been administered in the treatment of colic, continual patient reassessment by clinical examination should be maintained as drug induced analgesia may obscure the need for surgical intervention.First Aid If poisoning occurs, contact a doctor or Poisons Information Centre. Phone Australia 131 126.Disposal Dispose of empty container by wrapping with paper and putting in garbage.|
|Dosage and Administration||Horses. 2.2 mg/kg (10 mL/450 kg) bodyweight by deep intramuscular or slow intravenous injection, once daily for up to five days. Cattle. 3 mg/kg (3 mL/100 kg) bodyweight by slow intravenous or intramuscular injection in the anterior half of the neck, once daily for one to three days.|
|Storage||Store below 30°C (room temperature). Protect from light. Following withdrawal of the first dose, use the reminder of the vial within 28 days or discard the unused portion.|
|MSDS (external link)||Key Inj 100ml MSDS|
|Label (external link)||Key Inj 100ml Label|
|Manufacturer||Ceva Animal Health Pty Limited|